Easy does it
Giving baby the easier injection first helps with response to pain later on.
baby (Ablestock)
The order in which vaccine injections are given affects infants' pain response, new research shows.

During routine childhood immunization, infants given an injection of DPTaP-Hib vaccine before pneumococcal vaccine (PCV) experience less pain than those given the vaccines in the opposite order.

The finding suggests that when two vaccines are to be given, the less painful one -- in this case DPTaP-Hib -- should be given before the more painful one --in this case PCV.

"To our knowledge, the effect of varying the order in which vaccines of different degrees of painfulness are given has not been previously examined," Dr. Moshe Ipp, from The Hospital for Sick Children, Toronto, and co-researchers note in the Archives of Pediatrics and Adolescent Medicine.

Their trial included 120 healthy infants, 2 to 6 months of age, who were seen at a pediatric clinic in Toronto. The infants' pain was assessed using a standard behavioral pain scale and by parents' ratings.

Pain after both vaccine injections was significantly lower in the group of infants who were given DPTaP-Hib first and then PCV. This was seen with both the pain scale and the parents' assessment.

As to why the order of vaccinations affects the pain response, the investigators suggest that when the more painful injection is given first, it "focuses the infant's attention on the procedure and activates central and peripheral mechanisms of pain processing that together result in amplification of the pain signal during subsequent injections administered immediately thereafter."

Read Parent24’s Comments Policy

24.com publishes all comments posted on articles provided that they adhere to our Comments Policy. Should you wish to report a comment for editorial review, please do so by clicking the 'Report Comment' button to the right of each comment.

Comment on this story
Comments have been closed for this article.


Want to know what your baby looks like and what you can expect at this stage?




Balance routine and creativity

Little people need routine, but creative play is also essential. Try these activities with them to balance the two.

See more >


Everything from parties to pre-schools in your area.