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Flu shots safe for pregnant women

 
Studies show that there is no direct link between stillbirths and the flu shot.
By Amy Norton

Pic: Shutterstock

Article originally in Parent24
Adding to evidence that the flu shot is safe during pregnancy, a U.S. government study found no unusual complications among pregnant women who've received the vaccine in the past 20 years.

Researchers found that between 1990 and 2009, there were 175 reports of possibly vaccine-related medical complications among pregnant women submitted to the Vaccine Adverse Event Reporting System (VAERS).

That amounts to an estimated rate of 12.5 reported complications per 1 million pregnant women vaccinated against the flu.

Most were considered "non-serious." And while there were some reports of miscarriage and stillbirth, the numbers were substantially lower than the average rates of those complications in the general population.

VAERS is a vaccine-safety surveillance system run by the federal government; it allows anyone - including doctors, vaccine makers and vaccine recipients - to report health problems that develop after a vaccination.

Those reported problems are not necessarily caused by vaccination, so the VAERS system does not prove cause-and-effect. One of its goals is to help health officials spot new, unusual or rare side effects that may go undetected in the relatively small clinical studies done before and after a vaccine's approval.

The safety of the flu shot, which is made using killed influenza virus, has been studied in about 10,000 pregnant women, with no evidence that it presents a particular risk in this group.

These latest findings "add to the existing evidence that the (flu shot) is safe for pregnant women," lead researcher Dr. Pedro L. Moro, of the U.S. Centers for Disease Control and Prevention in Atlanta, told Reuters Health.

Public health officials, as well as medical groups like the American College of Obstetricians and Gynaecologists, recommend that all pregnant women receive the flu shot - though not the nasal-spray flu vaccine, which is made from a live, weakened virus.

Compared with non-pregnant women of the same age, expecting women are more likely to become seriously ill from flu infection and need hospitalization.

According to the CDC, pregnant women accounted for one in 20 deaths from H1N1 influenza (swine flu) in 2009. By comparison, only one in 100 was pregnant in the population.

That's why pregnant women are one of the "target groups" particularly encouraged to get the flu shot, Moro said.

Yet research indicates that no more than one-quarter of pregnant women in the U.S. got vaccinated during recent flu seasons. The reasons aren't clear, but doubts about the safety of the flu vaccine - among both pregnant women and their doctors - could be at work, Moro and his colleagues write in the American Journal of Obstetrics & Gynaecology.

They found 148 reports of complications in the VAERS system among pregnant women who had received flu shots between 1990 and 2009. Another 27 came from pregnant women who inadvertently received the nasal-spray vaccine between 2003 and 2009 - often because the women did not yet know they were pregnant or did not tell the health provider administering the vaccine.

Most of the reports - 88% - were classified as non-serious. 20% of flu-shot reports and 59% of those related to the nasal spray contained no specific complication; instead, they simply indicated that a pregnant woman had received the flu vaccine.

Among the most common complications were skin reactions at the injection site, symptoms like fever and fatigue, and mild allergic reactions.

There were 20 reports of miscarriage, amounting to an overall rate of two per one million vaccinated pregnant women. By comparison, between 10% and 20% of U.S. pregnant women suffer miscarriages, with the rate varying by age.

Moro pointed out that VAERS has its limits.

Being a "passive" surveillance that relies on receiving reports, it does not give an accurate estimate of the rate of miscarriage among all pregnant women who receive the flu shot, Still, Moro said, the current figures offer no reason for concern.

In general, the most common side effects of the flu shot are pain and swelling at the injection site, short-lived fever and muscle aches, and throat or eye irritation. Serious, life-threatening allergic reactions are possible, but very rare, according to the CDC.

Some, but not all, flu shots contain a mercury-based preservative called thimerosal. Despite concerns about a proposed link between thimerosal-containing vaccines and autism, numerous studies have found no association.

A projected 74 million doses of flu vaccine will be available for the 2010-2011 flu season in the U.S.

Have you had a flu shot while pregnant? What was your experience?
Read more on: pregnant  |  health  |  flu
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